Ontology highlight
ABSTRACT:
SUBMITTER: Erdemli SB
PROVIDER: S-EPMC3573878 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Erdemli Sabri B SB Gupta Radhika R Bishai William R WR Lamichhane Gyanu G Amzel L Mario LM Bianchet Mario A MA
Structure (London, England : 1993) 20121025 12
With multidrug-resistant cases of tuberculosis increasing globally, better antibiotic drugs and novel drug targets are becoming an urgent need. Traditional β-lactam antibiotics that inhibit D,D-transpeptidases are not effective against mycobacteria, in part because mycobacteria rely mostly on L,D-transpeptidases for biosynthesis and maintenance of their peptidoglycan layer. This reliance plays a major role in drug resistance and persistence of Mycobacterium tuberculosis (Mtb) infections. The cry ...[more]