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Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering.

ABSTRACT: We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.

SUBMITTER: Asiala SM

PROVIDER: S-EPMC3574179 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering.

Asiala Steven M SM Schultz Zachary D ZD

Chemical communications (Cambridge, England) 20121029 39

We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale. ...[more]

PMID: 23103901

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