Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.
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ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC3574187 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.
Lu Jia J Ye Xiangcang X Fan Fan F Xia Ling L Bhattacharya Rajat R Bellister Seth S Tozzi Federico F Sceusi Eric E Zhou Yunfei Y Tachibana Isamu I Maru Dipen M DM Hawke David H DH Rak Janusz J Mani Sendurai A SA Zweidler-McKay Patrick P Ellis Lee M LM
Cancer cell 20130131 2
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-cell contact, ECs secrete factors that promoted the CSC phenotype in CRC cells via Notch activation. In human CRC specimens, CD133 and Notch intracellular domain-positive CRC cells colocalized in perivascular regions. An EC-derived, soluble form of Jagged-1, via ADAM17 proteolytic activity, led to Notch activation in ...[more]
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