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Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation.

ABSTRACT: This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D(1) or D(2), antagonist. Antagonism of D(1), but not D(2), receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-? and IL-1?. This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D(1) receptors within the BLA.

SUBMITTER: Szczytkowski JL

PROVIDER: S-EPMC3574580 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation.

Szczytkowski Jennifer L JL Lysle Donald T DT

Journal of neuroimmunology 20100603 1-2

This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D(1) or D(2), antagonist. Antagonism of D(1), but not D(2), receptors within the BLA blocked the suppressive effect of ...[more]

PMID: 20605224

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