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Tracking X-ray microscopy for alveolar dynamics in live intact mice.

ABSTRACT: Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).

SUBMITTER: Chang S

PROVIDER: S-EPMC3575013 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Tracking X-ray microscopy for alveolar dynamics in live intact mice.

Chang Soeun S Kwon Namseop N Weon Byung Mook BM Kim Jinkyung J Rhee Chin Kook CK Choi Han Sung HS Kohmura Yoshiki Y Yamamoto Masaki M Ishikawa Tetsuya T Je Jung Ho JH

Scientific reports 20130101

Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar- ...[more]

PMID: 23416838

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