Ontology highlight
ABSTRACT:
SUBMITTER: Qian W
PROVIDER: S-EPMC3575687 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Qian Weiqiang W Miki Daisuke D Zhang Heng H Liu Yunhua Y Zhang Xi X Tang Kai K Kan Yunchao Y La Honggui H Li Xiaojie X Li Shaofang S Zhu Xiaohong X Shi Xiaobing X Zhang Kangling K Pontes Olga O Chen Xuemei X Liu Renyi R Gong Zhizhong Z Zhu Jian-Kang JK
Science (New York, N.Y.) 20120601 6087
Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 an ...[more]