Ontology highlight
ABSTRACT:
SUBMITTER: Meyer M
PROVIDER: S-EPMC3575704 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Meyer Michael M Müller Anna-Katharina AK Yang Jingxuan J Moik Daniel D Ponzio Gilles G Ornitz David M DM Grose Richard R Werner Sabine S
Journal of cell science 20120919 Pt 23
Efficient wound repair is essential for the maintenance of the integrity of the skin. The repair process is controlled by a variety of growth factors and cytokines, and their abnormal expression or activity can cause healing disorders. Here, we show that wound repair is severely delayed in mice lacking fibroblast growth factor receptors (FGFR) 1 and 2 in keratinocytes. As the underlying mechanism, we identified impaired wound contraction and a delay in re-epithelialization that resulted from imp ...[more]