Ontology highlight
ABSTRACT:
SUBMITTER: Landry MP
PROVIDER: S-EPMC3575837 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Nucleic acids research 20121228 4
Sequence-specific DNA-binding proteins must quickly and reliably localize specific target sites on DNA. This search process has been well characterized for monomeric proteins, but it remains poorly understood for systems that require assembly into dimers or oligomers at the target site. We present a single-molecule study of the target-search mechanism of protelomerase TelK, a recombinase-like protein that is only active as a dimer. We show that TelK undergoes 1D diffusion on non-target DNA as a ...[more]