Ontology highlight
ABSTRACT:
SUBMITTER: D'Cruz AA
PROVIDER: S-EPMC3575854 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
D'Cruz Akshay A AA Babon Jeffrey J JJ Norton Raymond S RS Nicola Nicos A NA Nicholson Sandra E SE
Protein science : a publication of the Protein Society 20130101 1
The SPRY domain is a protein interaction module found in 77 murine and ~100 human proteins, and is implicated in important biological pathways, including those that regulate innate and adaptive immunity. The current definition of the SPRY domain is based on a sequence repeat discovered in the splA kinase and ryanodine receptors. The greater SPRY family is divided into the B30.2 (which contains a PRY extension at the N-terminus) and "SPRY-only" sub-families. In this brief review, we examine the c ...[more]