Unknown

Dataset Information

0

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.


ABSTRACT: The SPRY domain is a protein interaction module found in 77 murine and ~100 human proteins, and is implicated in important biological pathways, including those that regulate innate and adaptive immunity. The current definition of the SPRY domain is based on a sequence repeat discovered in the splA kinase and ryanodine receptors. The greater SPRY family is divided into the B30.2 (which contains a PRY extension at the N-terminus) and "SPRY-only" sub-families. In this brief review, we examine the current structural and biochemical literature on SPRY/B30.2 domain involvement in key immune processes and highlight a PRY-like 60 amino acid region in the N-terminus of "SPRY-only" proteins. Phylogenetic, structural, and functional analyses suggest that this N-terminal region is related to the PRY region of B30.2 and should be characterized as part of an extended SPRY domain. Greater understanding of the functional importance of the N-terminal region in "SPRY only" proteins will enhance our ability to interrogate SPRY interactions with their respective binding partners.

SUBMITTER: D'Cruz AA 

PROVIDER: S-EPMC3575854 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.

D'Cruz Akshay A AA   Babon Jeffrey J JJ   Norton Raymond S RS   Nicola Nicos A NA   Nicholson Sandra E SE  

Protein science : a publication of the Protein Society 20130101 1


The SPRY domain is a protein interaction module found in 77 murine and ~100 human proteins, and is implicated in important biological pathways, including those that regulate innate and adaptive immunity. The current definition of the SPRY domain is based on a sequence repeat discovered in the splA kinase and ryanodine receptors. The greater SPRY family is divided into the B30.2 (which contains a PRY extension at the N-terminus) and "SPRY-only" sub-families. In this brief review, we examine the c  ...[more]

Similar Datasets

| S-EPMC1422157 | biostudies-literature
| S-EPMC1091705 | biostudies-literature
| S-EPMC2755966 | biostudies-literature
| S-EPMC2755863 | biostudies-literature
| S-EPMC4945854 | biostudies-literature
| S-EPMC6363617 | biostudies-literature
| S-EPMC4012390 | biostudies-literature
| S-EPMC6572098 | biostudies-literature
| S-EPMC2794661 | biostudies-literature
| S-EPMC2847656 | biostudies-literature