NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.
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ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC3575923 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.
Xu Xianzhong X Olson Cheryl L CL Engman David M DM Ames James B JB
Protein science : a publication of the Protein Society 20121026 12
Flagellar calcium binding proteins are expressed in a variety of trypanosomes and are potential drug targets for Chagas disease and African sleeping sickness. The flagellar calcium binding protein calflagin of Trypanosoma brucei (called Tb24) is a myristoylated and palmitoylated EF-hand protein that is targeted to the inner leaflet of the flagellar membrane. The Tb24 protein may also interact with proteins on the membrane surface that may be different from those bound to flagellar calcium bindin ...[more]
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