Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki-Anekoji M
PROVIDER: S-EPMC3576103 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Suzuki-Anekoji Misa M Suzuki Atsushi A Wu Sz-Wei SW Angata Kiyohiko K Murai Keith K KK Sugihara Kazuhiro K Akama Tomoya O TO Khoo Kay-Hooi KH Nakayama Jun J Fukuda Michiko N MN Fukuda Minoru M
The Journal of biological chemistry 20121226 7
Chst10 adds sulfate to glucuronic acid to form a carbohydrate antigen, HNK-1, in glycoproteins and glycolipids. To determine the role of Chst10 in vivo, we generated systemic Chst10-deficient mutant mice. Although Chst10(-/-) mice were born and grew to adulthood with no gross defects, they were subfertile. Uteri from Chst10(-/-) females at the pro-estrus stage were larger than those from wild-type females and exhibited a thick uterine endometrium. Serum estrogen levels in Chst10(-/-) females wer ...[more]