Ontology highlight
ABSTRACT:
SUBMITTER: Drong AW
PROVIDER: S-EPMC3576415 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Drong Alexander W AW Nicholson George G Hedman Asa K AK Meduri Eshwar E Grundberg Elin E Small Kerrin S KS Shin So-Youn SY Bell Jordana T JT Karpe Fredrik F Soranzo Nicole N Spector Tim D TD McCarthy Mark I MI Deloukas Panos P Rantalainen Mattias M Lindgren Cecilia M CM
PloS one 20130219 2
Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. We investigated whether meQTLs exist in abdominal subcutaneous adipose tissue (SAT) and if CpG methylation associates with metabolic syndrome (MetSyn) phenotypes. We profiled 27,718 genomic regions in abdominal SAT samples of 38 unrelated individuals using differential methylation hybridization (DMH) together ...[more]