Ontology highlight
ABSTRACT:
SUBMITTER: Schafer A
PROVIDER: S-EPMC3576512 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Schäfer Andrea A Karaulanov Emil E Stapf Ulrike U Döderlein Gabi G Niehrs Christof C
Genes & development 20130201 3
Active DNA demethylation regulates epigenetic gene activation in numerous processes, but how the target site specificity of DNA demethylation is determined and what factors are involved are still poorly understood. Here we show that the tumor suppressor inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation. Ing1 functions by recruiting the regulator of DNA demethylation growth arrest and DNA damage protein 45a (Gadd45a) to histone H3 trimethylated at Lys 4 (H3K4 ...[more]