Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.
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ABSTRACT:
SUBMITTER: Chooi YH
PROVIDER: S-EPMC3576815 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.
Chooi Yit-Heng YH Fang Jinxu J Liu Hong H Filler Scott G SG Wang Pin P Tang Yi Y
Organic letters 20130131 4
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological role as an immunosuppressive agent. ...[more]
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