Ontology highlight
ABSTRACT:
SUBMITTER: Gao Z
PROVIDER: S-EPMC3577055 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Gao Zhizeng Z Wang Jingjing J Norquay Amy K AK Qiao Kangjian K Tang Yi Y Vederas John C JC
Journal of the American Chemical Society 20130128 5
Iterative polyketide synthases (PKSs) are large, multifunctional enzymes that resemble eukaryotic fatty acid synthases but can make highly functionalized secondary metabolites using complex and unresolved programming rules. During biosynthesis of the kinase inhibitor hypothemycin by Hypomyces subiculosus , a highly reducing iterative PKS, Hpm8, cooperates with a nonreducing iterative PKS, Hpm3, to construct the advanced intermediate dehydrozearalenol (DHZ). The identity of putative intermediate ...[more]