PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis.

ABSTRACT:

Background

The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis. To date, studies investigated the association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive results.

Methods

A meta-analysis based on 25 case-control studies was performed to address this issue. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with I(2) test.

Results

Overall, a significant increased risk of cancer was associated with the PAI-1 4G/4G polymorphism for the allele contrast (4G vs. 5G: OR?=?1.10, CI?=?1.03-1.18, I(2)?=?49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR?=?1.21, CI?=?1.06-1.39, I(2)?=?51.9%), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G: OR?=?1.11, CI?=?1.04-1.18, I(2)?=?20.8%). In the subgroup analysis by ethnicity, the results indicated that individuals with 4G/4G genotype had a significantly higher cancer risk among Caucasians (4G/4G vs. 5G/5G: OR?=?1.31, 95%CI?=?1.09-1.59, I(2)?=?59.6%; 4G/4G vs. 4G/5G: OR?=?1.12, 95%CI?=?1.04-1.21, I(2)?=?3.6%; recessive model: OR?=?1.12, 95%CI?=?1.05-1.21, I(2)?=?25.3%).

Conclusions

The results of the present meta-analysis support an association between the PAI-1 4G/5G polymorphism and increasing cancer risk, especially among Caucasians, and those with 4G allele have a high risk to develop colorectal cancer and endometrial cancer.

SUBMITTER: Wang S 

PROVIDER: S-EPMC3577655 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature