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ABSTRACT:
SUBMITTER: Gerard B
PROVIDER: S-EPMC3577964 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
ACS combinatorial science 20121022 11
A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric Povarov reaction using cooperative catalysis to generate three contiguous stereogenic centers. A matrix of 4 stereoisomers of the THQ scaffold was prepared to enable the development of stereo/structure-activity relationships (SSAR) upon biological testing. A sparse matrix design ...[more]