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ABSTRACT:
SUBMITTER: Goswami LN
PROVIDER: S-EPMC3577990 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Goswami Lalit N LN Ma Lixin L Chakravarty Shatadru S Cai Quanyu Q Jalisatgi Satish S SS Hawthorne M Frederick MF
Inorganic chemistry 20121105 4
An icosahedral closo-B(12)(2-) scaffold supports 12 copies of Gd(3+)-chelate held in close proximity with each other by suitable linkers which employ azide-alkyne click chemistry. This design is the first member of a new class of polyfunctional MRI contrast agents carrying a high payload of Gd(3+)-chelate in a sterically constrained configuration. The resulting contrast agent shows higher relaxivity values at high magnetic fields. MRI contrast agents currently in use are not as effective in this ...[more]