Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Hernandez-Gea V
PROVIDER: S-EPMC3578068 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.
Hernandez-Gea Virginia V Toffanin Sara S Friedman Scott L SL Llovet Josep M JM
Gastroenterology 20130109 3
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite the significant improvement in management of HCC over the past 30 years, there are no effective chemoprevention strategies, and only one systemic therapy has been approved for patients with advanced tumors. This drug, sorafenib, acts on tumor cells and the stroma. HCC develops from chronically damaged tissue that contains l ...[more]
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