Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HN
PROVIDER: S-EPMC3578553 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Nguyen Ha Nam HN Byers Blake B Cord Branden B Shcheglovitov Aleksandr A Byrne James J Gujar Prachi P Kee Kehkooi K Schüle Birgitt B Dolmetsch Ricardo E RE Langston William W Palmer Theo D TD Pera Renee Reijo RR
Cell stem cell 20110301 3
Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation (G2019S-iPSCs) in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene, the most common PD-related mutation, and their differentiation into DA neurons. The high penetrance of the LRRK2 mutation and its clinical resemblance to sporadic PD suggest that these cells could provide a valuable platfor ...[more]