Ontology highlight
ABSTRACT:
SUBMITTER: Shipley RJ
PROVIDER: S-EPMC3579239 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Shipley R J RJ Davidson A J AJ Chan K K Chaudhuri J B JB Waters S L SL Ellis M J MJ
Biotechnology and bioengineering 20110302 6
The development of tissue engineering hollow fiber bioreactors (HFB) requires the optimal design of the geometry and operation parameters of the system. This article provides a strategy for specifying operating conditions for the system based on mathematical models of oxygen delivery to the cell population. Analytical and numerical solutions of these models are developed based on Michaelis-Menten kinetics. Depending on the minimum oxygen concentration required to culture a functional cell popula ...[more]