Unknown

Dataset Information

0

Urinary cystatin C and tubular proteinuria predict progression of diabetic nephropathy.


ABSTRACT:

Objective

The aim of this study was to evaluate the association of urinary cystatin C, a tubular damage marker, with the progression of type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS: The baseline values of serum and urinary cystatin C were measured as primary parameters and those of urinary nonalbumin protein (NAP) were measured as secondary parameters. In this prospective observational study, a total of 237 type 2 diabetic patients were followed up for 29 months (13-44 months).

Results

Both the urinary cystatin C-to-creatinine ratio (CCR) and NAP-to-creatinine ratio (NAPCR) were significantly different according to the degree of albuminuria. Both markers had strongly positive correlations at baseline. After adjusting for several clinical factors, both urinary CCR and NAPCR had significant associations with the decline of the estimated glomerular filtration rate (eGFR) (r = 0.160, P = 0.021; r = 0.412, P < 0.001, respectively). Urinary CCR had positive correlations with the decline of eGFR in the subpopulation of patients with eGFR ?60 mL/min/1.73 m(2). In patients with eGFR ?60 mL/min/1.73 m(2) and normoalbuminuria, only urinary NAPCR showed a significant association with the decline of eGFR; urinary CCR did not. In multivariate regression analysis, the number of patients who progressed to chronic kidney disease stage 3 or greater was higher in those in the upper tertiles of both the urinary levels of cystatin C and NAP than in those in the lower tertiles.

Conclusions

The results of this study suggest that urinary cystatin C and NAP may be predictors of the progression of type 2 diabetic nephropathy.

SUBMITTER: Kim SS 

PROVIDER: S-EPMC3579333 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Urinary cystatin C and tubular proteinuria predict progression of diabetic nephropathy.

Kim Sang Soo SS   Song Sang Heon SH   Kim In Joo IJ   Jeon Yun Kyung YK   Kim Bo Hyun BH   Kwak Ihm Soo IS   Lee Eun Kyung EK   Kim Yong Ki YK  

Diabetes care 20121023 3


<h4>Objective</h4>The aim of this study was to evaluate the association of urinary cystatin C, a tubular damage marker, with the progression of type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS: The baseline values of serum and urinary cystatin C were measured as primary parameters and those of urinary nonalbumin protein (NAP) were measured as secondary parameters. In this prospective observational study, a total of 237 type 2 diabetic patients were followed up for 29 months (13-44 months)  ...[more]

Similar Datasets

| S-EPMC4247804 | biostudies-literature
| S-EPMC4893561 | biostudies-literature
| S-EPMC3699823 | biostudies-other
| S-EPMC3789480 | biostudies-literature
2018-05-22 | PXD009303 | Pride
| S-EPMC4485941 | biostudies-literature
| S-EPMC3964498 | biostudies-literature
2016-11-03 | E-MTAB-4166 | biostudies-arrayexpress
| S-EPMC6802630 | biostudies-literature
| S-EPMC3817183 | biostudies-literature