DNA repair by reversal of DNA damage.
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ABSTRACT:
SUBMITTER: Yi C
PROVIDER: S-EPMC3579392 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
DNA repair by reversal of DNA damage.
Cold Spring Harbor perspectives in biology 20130101 1
Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to reverse covalent DNA adducts. In this review, we focus on recent advances in the field of direct DNA repair, namely, photolyase-, alkyltransferase-, an ...[more]
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