Ontology highlight
ABSTRACT:
SUBMITTER: Haudecoeur R
PROVIDER: S-EPMC3579765 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110706 15
We have identified naturally occurring 2-benzylidenebenzofuran-3-ones (aurones) as new templates for non-nucleoside hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors. The aurone target site, identified by site-directed mutagenesis, is located in thumb pocket I of HCV RdRp. The RdRp inhibitory activity of 42 aurones was rationally explored in an enzyme assay. Molecular docking studies were used to determine how aurones bind to HCV RdRp and to predict their range of inhibitory ...[more]