Ontology highlight
ABSTRACT:
SUBMITTER: Kellner ES
PROVIDER: S-EPMC3580233 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Kellner Erinn S ES Lee Pui Y PY Li Yi Y Switanek Juliana J Zhuang Haoyang H Segal Mark S MS Sobel Eric S ES Satoh Minoru M Reeves Westley H WH
Journal of neuroimmunology 20100422 1-2
Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longit ...[more]