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Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.


ABSTRACT: Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.

SUBMITTER: Kellner ES 

PROVIDER: S-EPMC3580233 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.

Kellner Erinn S ES   Lee Pui Y PY   Li Yi Y   Switanek Juliana J   Zhuang Haoyang H   Segal Mark S MS   Sobel Eric S ES   Satoh Minoru M   Reeves Westley H WH  

Journal of neuroimmunology 20100422 1-2


Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longit  ...[more]

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