Dataset Information

(18)F-florbetaben A? imaging in mild cognitive impairment.

ABSTRACT:

Introduction

(18)F-florbetaben and positron emission tomography were used to examine the relationships between ?-amyloid (A?) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).

Methods

Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ? 1.45 was used to discriminate high from low A? burden. Correlations were adjusted for age, gender and years of education.

Results

High A? burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with A? burden.

Conclusion

Higher A? deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.

SUBMITTER: Ong K

PROVIDER: S-EPMC3580329 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

(18)F-florbetaben Aβ imaging in mild cognitive impairment.

Ong Kevin K Villemagne Victor L VL Bahar-Fuchs Alex A Lamb Fiona F Chételat Gaël G Raniga Parnesh P Mulligan Rachel S RS Salvado Olivier O Putz Barbara B Roth Katrin K Masters Colin L CL Reininger Cornelia B CB Rowe Christopher C CC

Alzheimer's research & therapy 20130116 1

<h4>Introduction</h4>(18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).<h4>Methods</h4>Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.<h4>Results</h4 ...[more]

PMID: 23324163

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