Dataset Information

Brain natriuretic peptide for prediction of mortality in patients with sepsis: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Early identification of septic patients at high risk of dying remains a challenge. The prognostic role of brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in septic patients remains controversial. The purpose of this systematic review and meta-analysis was to investigate the value of elevated BNP or NT-proBNP in predicting mortality in septic patients.

Methods

PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched (up to February 18, 2011). Studies were included if they had prospectively collected data on all-cause mortality in adult septic patients with either plasma BNP or NT-proBNP measurement. Studies that failed to construct a 2 × 2 table of results were excluded. Two authors independently determined the validity of included studies and extracted data.

Results

12 studies with a total of 1,865 patients were included. Elevated natriuretic peptides were significantly associated with increased risk of mortality (odds ratio (OR) 8.65, 95% confidence interval (CI) 4.94 to 15.13, P < 0.00001). The association was consistent for BNP (OR 10.44, 95% CI 4.99 to 21.58, P < 0.00001) and NT-proBNP (OR 6.62, 95% CI 2.68 to 16.34, P < 0.0001). The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 79% (95% CI 75 to 83), 60% (95% CI 57 to 62), 2.27 (95% CI 1.83 to 2.81) and 0.32 (95% CI 0.22 to 0.46), respectively.

Conclusions

Our results suggested that an elevated BNP or NT-proBNP level may prove to be a powerful predictor of mortality in septic patients. Future larger and more adequately powered prospective studies are warranted to clarify the assay standardization, the optimal cut-off, and the prognostic value of BNPs in conjunction with other biomarkers.

SUBMITTER: Wang F

PROVIDER: S-EPMC3580616 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Publications

Brain natriuretic peptide for prediction of mortality in patients with sepsis: a systematic review and meta-analysis.

Wang Fei F Wu Youping Y Tang Lu L Zhu Weimin W Chen Feng F Xu Tao T Bo Lulong L Li Jinbao J Deng Xiaoming X

Critical care (London, England) 20120506 3

<h4>Introduction</h4>Early identification of septic patients at high risk of dying remains a challenge. The prognostic role of brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in septic patients remains controversial. The purpose of this systematic review and meta-analysis was to investigate the value of elevated BNP or NT-proBNP in predicting mortality in septic patients.<h4>Methods</h4>PubMed, Embase and the Cochrane Central Register of Controlled Trials ...[more]

PMID: 22559153

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Dataset Information

Brain natriuretic peptide for prediction of mortality in patients with sepsis: a systematic review and meta-analysis.

Introduction

Methods

Results

Conclusions

Publications

Brain natriuretic peptide for prediction of mortality in patients with sepsis: a systematic review and meta-analysis.

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