DISC1 genetics, biology and psychiatric illness.
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ABSTRACT:
SUBMITTER: Thomson PA
PROVIDER: S-EPMC3580875 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
DISC1 genetics, biology and psychiatric illness.
Thomson Pippa A PA Malavasi Elise L V EL Grünewald Ellen E Soares Dinesh C DC Borkowska Malgorzata M Millar J Kirsty JK
Frontiers in biology 20130201 1
Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon ...[more]
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