Ontology highlight
ABSTRACT:
SUBMITTER: Tabassum R
PROVIDER: S-EPMC3581193 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tabassum Rubina R Chauhan Ganesh G Dwivedi Om Prakash OP Mahajan Anubha A Jaiswal Alok A Kaur Ismeet I Bandesh Khushdeep K Singh Tejbir T Mathai Benan John BJ Pandey Yogesh Y Chidambaram Manickam M Sharma Amitabh A Chavali Sreenivas S Sengupta Shantanu S Ramakrishnan Lakshmi L Venkatesh Pradeep P Aggarwal Sanjay K SK Ghosh Saurabh S Prabhakaran Dorairaj D Srinath Reddy K RK Saxena Madhukar M Banerjee Monisha M Mathur Sandeep S Bhansali Anil A Shah Viral N VN Madhu Sri Venkata SV Marwaha Raman K RK Basu Analabha A Scaria Vinod V McCarthy Mark I MI Venkatesan Radha R Mohan Viswanathan V Tandon Nikhil N Bharadwaj Dwaipayan D
Diabetes 20121203 3
Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes-associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 × 10⁻⁹). Imputation analysis refined the signal to rs998451 (odds ratio 1.56; P = 6.3 × 10⁻¹²) within TMEM163 that encodes a probabl ...[more]