Ontology highlight
ABSTRACT:
SUBMITTER: Song K
PROVIDER: S-EPMC3581251 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Song Kai K Ren Jie J Zhai Zhiyuan Z Liu Xuemei X Deng Minghua M Sun Fengzhu F
Journal of computational biology : a journal of computational molecular cell biology 20130201 2
Next-generation sequencing (NGS) technologies have generated enormous amounts of shotgun read data, and assembly of the reads can be challenging, especially for organisms without template sequences. We study the power of genome comparison based on shotgun read data without assembly using three alignment-free sequence comparison statistics, D(2), D(*)(2) and D(s)(2), both theoretically and by simulations. Theoretical formulas for the power of detecting the relationship between two sequences relat ...[more]