Ontology highlight
ABSTRACT:
SUBMITTER: Song P
PROVIDER: S-EPMC3581390 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Song Parkyong P Kim Jong Hyun JH Ghim Jaewang J Yoon Jong Hyuk JH Lee Areum A Kwon Yonghoon Y Hyun Hyunjung H Moon Hyo-Youl HY Choi Hueng-Sik HS Berggren Per-Olof PO Suh Pann-Ghill PG Ryu Sung Ho SH
The Journal of biological chemistry 20130109 8
AMP-activated protein kinase has been described as a key signaling protein that can regulate energy homeostasis. Here, we aimed to characterize novel AMP-activated kinase (AMPK)-activating compounds that have a much lower effective concentration than metformin. As a result, emodin, a natural anthraquinone derivative, was shown to stimulate AMPK activity in skeletal muscle and liver cells. Emodin enhanced GLUT4 translocation and [(14)C]glucose uptake into the myotube in an AMPK-dependent manner. ...[more]