Ontology highlight
ABSTRACT:
SUBMITTER: Lin YW
PROVIDER: S-EPMC3581494 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lin Yi-Wen YW Yu Shu-Ling SL Shao Hsiao-Yun HY Lin Hsiang-Yin HY Liu Chia-Chyi CC Hsiao Kuang-Nan KN Chitra Ebenezer E Tsou Yueh-Liang YL Chang Hsuen-Wen HW Sia Charles C Chong Pele P Chow Yen-Hung YH
PloS one 20130225 2
Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in children. Lack of a reliable animal model is an issue in investigating EV71-induced disease manifestation in humans, and the current clinical therapies are symptomatic. We generated a novel EV71-infectious model with hSCARB2-transgenic mice expressing the discovered receptor human SCARB2 (hSCARB2). The challenge of hSCARB2-transgenic mice wit ...[more]