Ontology highlight
ABSTRACT:
SUBMITTER: Valiente-Echeverria F
PROVIDER: S-EPMC3581557 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Valiente-Echeverría Fernando F Vallejos Maricarmen M Monette Anne A Pino Karla K Letelier Alejandro A Huidobro-Toro J Pablo JP Mouland Andrew J AJ López-Lastra Marcelo M
PloS one 20130225 2
Translation initiation from the human immunodeficiency virus type-1 (HIV-1) mRNA can occur through a cap or an IRES dependent mechanism. Cap-dependent translation initiation of the HIV-1 mRNA can be inhibited by the instability element (INS)-1, a cis-acting regulatory element present within the gag open reading frame (ORF). In this study we evaluated the impact of the INS-1 on HIV-1 IRES-mediated translation initiation. Using heterologous bicistronic mRNAs, we show that the INS-1 negatively impa ...[more]