Ontology highlight
ABSTRACT:
SUBMITTER: Wei C
PROVIDER: S-EPMC3581580 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wei Chunyao C Thatcher Elizabeth J EJ Olena Abigail F AF Cha Diana J DJ Perdigoto Ana L AL Marshall Andrew F AF Carter Bruce D BD Broadie Kendal K Patton James G JG
PloS one 20130225 2
SNAP-25 is a core component of the trimeric SNARE complex mediating vesicle exocytosis during membrane addition for neuronal growth, neuropeptide/growth factor secretion, and neurotransmitter release during synaptic transmission. Here, we report a novel microRNA mechanism of SNAP-25 regulation controlling motor neuron development, neurosecretion, synaptic activity, and movement in zebrafish. Loss of miR-153 causes overexpression of SNAP-25 and consequent hyperactive movement in early zebrafish e ...[more]