Ontology highlight
ABSTRACT:
SUBMITTER: Santidrian AF
PROVIDER: S-EPMC3582128 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Santidrian Antonio F AF Matsuno-Yagi Akemi A Ritland Melissa M Seo Byoung B BB LeBoeuf Sarah E SE Gay Laurie J LJ Yagi Takao T Felding-Habermann Brunhilde B
The Journal of clinical investigation 20130215 3
Despite advances in clinical therapy, metastasis remains the leading cause of death in breast cancer patients. Mutations in mitochondrial DNA, including those affecting complex I and oxidative phosphorylation, are found in breast tumors and could facilitate metastasis. This study identifies mitochondrial complex I as critical for defining an aggressive phenotype in breast cancer cells. Specific enhancement of mitochondrial complex I activity inhibited tumor growth and metastasis through regulati ...[more]