Ontology highlight
ABSTRACT:
SUBMITTER: Rousselle A
PROVIDER: S-EPMC3582141 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20130208 3
The ELR(+)-CXCL chemokines have been described typically as potent chemoattractants and activators of neutrophils during the acute phase of inflammation. Their role in atherosclerosis, a chronic inflammatory vascular disease, has been largely unexplored. Using a mouse model of atherosclerosis, we found that CXCL5 expression was upregulated during disease progression, both locally and systemically, but was not associated with neutrophil infiltration. Unexpectedly, inhibition of CXCL5 was not bene ...[more]