Aplysqualenol?A binds to the light chain of dynein type 1 (DYNLL1).
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ABSTRACT:
SUBMITTER: Vera B
PROVIDER: S-EPMC3582901 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1).
Vera Brunilda B Rodríguez Abimael D AD La Clair James J JJ
Angewandte Chemie (International ed. in English) 20110708 35
A bidirectional affinity system has been developed for the identification of cancer-related natural products and their biological targets. Aplysqualenol A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small-molecule isolation and target identification can be conducted using conventional molecular biological methods. ...[more]
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