Genetic variability in platelet integrin ?2?1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia.
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ABSTRACT:
SUBMITTER: Campos FM
PROVIDER: S-EPMC3583325 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
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Genetic variability in platelet integrin α2β1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia.
Campos Fernanda M F FM Santos Marina L S ML Kano Flora S FS Fontes Cor J F CJ Lacerda Marcus V G MV Brito Cristiana F A CF Carvalho Luzia H LH
The American journal of tropical medicine and hygiene 20121218 2
Understanding the pathogenesis of Plasmodium vivax malaria is challenging. We hypothesized that susceptibility to P. vivax-induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin α2 (C807T), and integrin β3 (T1565C). Although β3 polymorphism was not related with P. vivax malaria, α2 807T carriers, which show high levels of integrin α2β1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the ass ...[more]
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