Ontology highlight
ABSTRACT:
SUBMITTER: Just S
PROVIDER: S-EPMC3583494 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Just Sascha S Illing Susann S Trester-Zedlitz Michelle M Lau Elaine K EK Kotowski Sarah J SJ Miess Elke E Mann Anika A Doll Christian C Trinidad Jonathan C JC Burlingame Alma L AL von Zastrow Mark M Schulz Stefan S
Molecular pharmacology 20121213 3
Differences in the ability of opioid drugs to promote regulated endocytosis of μ-opioid receptors are related to their tendency to produce drug tolerance and dependence. Here we show that drug-specific differences in receptor internalization are determined by a conserved, 10-residue sequence in the receptor's carboxyl-terminal cytoplasmic tail. Diverse opioids induce receptor phosphorylation at serine (S)375, present in the middle of this sequence, but opioids differ markedly in their ability to ...[more]