Ontology highlight
ABSTRACT:
SUBMITTER: Tam LW
PROVIDER: S-EPMC3583663 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tam Lai-Wa LW Ranum Paul T PT Lefebvre Paul A PA
Molecular biology of the cell 20130102 5
The length of Chlamydomonas flagella is tightly regulated. Mutations in four genes-LF1, LF2, LF3, and LF4-cause cells to assemble flagella up to three times wild-type length. LF2 and LF4 encode protein kinases. Here we describe a new gene, LF5, in which null mutations cause cells to assemble flagella of excess length. The LF5 gene encodes a protein kinase very similar in sequence to the protein kinase CDKL5. In humans, mutations in this kinase cause a severe form of juvenile epilepsy. The LF5 pr ...[more]