SET protein up-regulated testosterone production in the cultured preantral follicles.
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ABSTRACT:
SUBMITTER: Xu B
PROVIDER: S-EPMC3583798 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
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SET protein up-regulated testosterone production in the cultured preantral follicles.
Xu Boqun B Gao Lingling L Cui Yugui Y Gao Li L Dai Xue X Li Mei M Zhang Yuan Y Ma Xiang X Diao Feiyang F Liu Jiayin J
Reproductive biology and endocrinology : RB&E 20130219
<h4>Background</h4>We found previously that the expression of SET gene was up-regulated in polycystic ovaries. Evidences suggested that SET protein was essential for regulating both the promoter activity of CYP17A1 and the biological activity of P450c17. In this study, we explored whether SET regulated androgen production in preantral follicles.<h4>Methods</h4>The mouse preantral follicles were cultured in vitro. Testosterone secretion and expression of steroidogenic enzymes were observed in the ...[more]
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