Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC3584418 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Wang Min M Yang Yang Y Wang Ching-Jung CJ Gamo Nao J NJ Jin Lu E LE Mazer James A JA Morrison John H JH Wang Xiao-Jing XJ Arnsten Amy F T AF
Neuron 20130201 4
Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the absence of sensory stimulation, the foundation of mental representation. Persistent firing arises from recurrent excitation within a network of pyramidal Delay cells. Here, we examined glutamate receptor influences underlying persistent firing in primate dlPFC during a spatial working memory task. Computational models predicted dependence on NMDA receptor (NMDAR) NR2B stimulation, and Delay cell persi ...[more]