Ontology highlight
ABSTRACT:
SUBMITTER: Vadhvani M
PROVIDER: S-EPMC3585373 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Vadhvani Mayur M Schwedhelm-Domeyer Nicola N Mukherjee Chaitali C Stegmüller Judith J
PloS one 20130228 2
Neuronal development requires proper migration, polarization and establishment of axons and dendrites. Growing evidence identifies the ubiquitin proteasome system (UPS) with its numerous components as an important regulator of various aspects of neuronal development. F-box proteins are interchangeable subunits of the Cullin-1 based E3 ubiquitin ligase, but only a few family members have been studied. Here, we report that the centrosomal E3 ligase FBXO31-SCF (Skp1/Cullin-1/F-box protein) regulate ...[more]