Ontology highlight
ABSTRACT:
SUBMITTER: Ridky TW
PROVIDER: S-EPMC3586217 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Ridky Todd W TW Chow Jennifer M JM Wong David J DJ Khavari Paul A PA
Nature medicine 20101121 12
Refined cancer models are required if researchers are to assess the burgeoning number of potential targets for cancer therapeutics in a clinically relevant context that allows a fast turnaround. Here we use tumor-associated genetic pathways to transform primary human epithelial cells from the epidermis, oropharynx, esophagus and cervix into genetically defined tumors in a human three-dimensional (3D) tissue environment that incorporates cell-populated stroma and intact basement membrane. These e ...[more]