Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC3586374 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Zhou Miou M Li Weidong W Huang Shan S Song Juan J Kim Ju Young JY Tian Xiaoli X Kang Eunchai E Sano Yoshitake Y Liu Cindy C Balaji J J Wu Shumin S Zhou Yu Y Zhou Ying Y Parivash Sherveen N SN Ehninger Dan D He Lin L Song Hongjun H Ming Guo-Li GL Silva Alcino J AJ
Neuron 20130201 4
Abnormalities during brain development are thought to cause psychiatric illness and other neurodevelopmental disorders. However, developmental processes such as neurogenesis continue in restricted brain regions of adults, and disruptions of these processes could contribute to the phenotypes of neurodevelopmental disorders. As previously reported, we show that Disc1 knockdown specifically in adult-born dentate gyrus (DG) neurons results in increased mTOR signaling, hyperexcitability, and neuronal ...[more]