Differences in gene expression between the otic capsule and other bones.
Ontology highlight
ABSTRACT:
SUBMITTER: Stankovic KM
PROVIDER: S-EPMC3586807 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Differences in gene expression between the otic capsule and other bones.
Stankovic Konstantina M KM Adachi Osamu O Tsuji Kunikazu K Kristiansen Arthur G AG Adams Joe C JC Rosen Vicki V McKenna Michael J MJ
Hearing research 20100208 1-2
Our long term goal is to understand the molecular pathology of otosclerosis and to develop better forms of therapy. Toward this goal, the current study focused on characterizing the molecular factors responsible for the unique biological features of the otic capsule: its minimal rate of remodeling, and lack of healing capacity when fractured. We compared expression levels of 62 genes involved in bone metabolism between the adult murine otic capsule and the tibia and parietal bones; the latter ex ...[more]
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