Ontology highlight
ABSTRACT:
SUBMITTER: Aragon JP
PROVIDER: S-EPMC3586978 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Aragón Juan P JP Condit Marah E ME Bhushan Shashi S Predmore Benjamin L BL Patel Sandeep S SS Grinsfelder D Bennett DB Gundewar Susheel S Jha Saurabh S Calvert John W JW Barouch Lili A LA Lavu Madhav M Wright Harold M HM Lefer David J DJ
Journal of the American College of Cardiology 20111201 25
<h4>Objectives</h4>This paper examined whether nebivolol protects the heart via nitric oxide (NO) synthase and NO-dependent signaling in an in vivo model of acute myocardial infarction.<h4>Background</h4>Beta(3)-adrenergic receptor (AR) activation promotes endothelial nitric oxide synthase (eNOS) activity and NO bioavailability. We hypothesized that specific beta(3)-AR agonists would attenuate myocardial ischemia-reperfusion (MI/R) injury via eNOS activation and increased NO bioavailability.<h4> ...[more]