Ontology highlight
ABSTRACT:
SUBMITTER: Welsh JL
PROVIDER: S-EPMC3587047 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Welsh J L JL Wagner B A BA van't Erve T J TJ Zehr P S PS Berg D J DJ Halfdanarson T R TR Yee N S NS Bodeker K L KL Du J J Roberts L J LJ Drisko J J Levine M M Buettner G R GR Cullen J J JJ
Cancer chemotherapy and pharmacology 20130205 3
<h4>Background</h4>Treatment for pancreatic cancer with pharmacological ascorbate (ascorbic acid, vitamin C) decreases tumor progression in preclinical models. A phase I clinical trial was performed to establish safety and tolerability of pharmacological ascorbate combined with gemcitabine in patients with biopsy-proven stage IV pancreatic adenocarcinoma.<h4>Design</h4>Nine subjects received twice-weekly intravenous ascorbate (15-125 g) employing Simon's accelerated titration design to achieve a ...[more]