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Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.

ABSTRACT: Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.

SUBMITTER: Qian J 

PROVIDER: S-EPMC3587177 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.

Qian Jiang J   Klomsiri Chananat C   Wright Marcus W MW   King S Bruce SB   Tsang Allen W AW   Poole Leslie B LB   Furdui Cristina M CM  

Chemical communications (Cambridge, England) 20110708 32

Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione. ...[more]

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