Positive and negative feedback loops in the p53 and mRNA 3' processing pathways.
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ABSTRACT:
SUBMITTER: Devany E
PROVIDER: S-EPMC3587245 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Positive and negative feedback loops in the p53 and mRNA 3' processing pathways.
Devany Emral E Zhang Xiaokan X Park Ji Yeon JY Tian Bin B Kleiman Frida Esther FE
Proceedings of the National Academy of Sciences of the United States of America 20130211 9
Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the p53 mRNA. Here, we provide evidence of a feedback loop between p53 and the poly(A)-specific ribonuclease (PARN), in which PARN deadenylase keeps p53 levels low in nonstress conditio ...[more]
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